Backed by science.

#1 Longevity Supplement
Ranked by an independent lab*

*Rejuvant Emerges as No. 1 Longevity Solution

Buck Institute on Aging studies reveal Rejuvant’s ingredients hold the promise to reverse epigenetic aging.
Preliminary research at the Buck Institute on Aging, the preeminent independent research facility dedicated solely to aging research, showed sustained-release Calcium Alpha-Ketoglutarate may be an effective strategy in slowing down the aging process. In their landmark mammal study, Rejuvant’s LifeAKG™ increased the healthiest years of life by 41% and reduced the manifestations of age-related frailty by 46%.
Rigorous research leads to precise formulation.
Unlike many others in the supplement industry, Rejuvant® was developed with meticulous scientific research. Millions of dollars, and years of research confirmed our hypothesis that Calcium Alpha-Ketoglutarate in specific combinations can delay the aging process. More than a dozen separate laboratory trials evaluated multiple compounds on mammals to assess effectiveness. Hundreds of combinations of these compounds led to the development of Rejuvant LifeAKG. 

And because we discovered Calcium Alpha-Ketoglutarate was metabolized differently in males and females, we formulated Rejuvant differently, too. To increase the potency for men, we included vitamin A. For the women’s dosage, we added vitamin D3.

Patent-pending delivery mechanism.
We tested hundreds of formulations before we developed our proprietary tablets. We formulated our proprietary calcium alpha-ketoglutarate, LifeAKG, in a sustained release matrix to prevent it from being absorbed too quickly. We then combined the LifeAKG with vitamin A and D to make our proprietary formulas for men and women. You need only two tablets, once a day, to live a healthier life.
Safe and effective as documented in peer-reviewed publications.
Rejuvant is made from the same naturally occurring ingredients in your own body: Calcium Alpha-Ketoglutarate. Research studies in the most respected scientific journals in the world—including Cell Magazine, Science, Lancet, Clinical Toxicology, and the National Center for Biotechnology Information at NIH—confirm the safety for humans of Calcium Alpha-Ketoglutarate when taken as directed.
Manufactured to the highest standards of purity.
We manufacture Rejuvant in the US, on a standard production line. Unlike most other supplements, our patented manufacturing process uses a purpose built production line dedicated solely to Rejuvant, including a biologically-pure USP water filtration system, so we can guarantee Rejuvant’s purity. Rejuvant produces AKG that is proprietary to Ponce De Leon Health, sustained release to maximize delivery, and over 98% pure.
Gauge your age: true biological age testing.
While your chronological age is the number of years that you’ve been alive, your biological age is the true reflection of how your cells are aging. Your biological age is best revealed through DNA analysis. Rejuvant has partnered with TrueMe Labs, makers of TrueAge Index, the first-ever direct to consumer epigenetic test, to allow you to see how your biological age compares to your chronological age and how it can change over time with additional testing. 

Taking the test is easy. Send a small amount of your saliva to TruMe Labs—an independent laboratory run by Stanford and Harvard-trained scientists—with the collection materials provided. TruMe will process your genomic DNA and compare it to profiles of the human genome to create biomarkers for your unique aging pattern. These results are correlated into a TrueAge Index™, reflecting age-related changes in your metabolism, physiology, and lifestyle which together make up your true biological age. 

To most effectively monitor your aging process, we recommend tracking your TruAge Index when you begin taking Rejuvant, and again after six months. Using the results in the TrueAge report will provide insight into your changing DNA methylation patterns and enable you to track your true biological age.

Selected Studies supporting Rejuvant with LifeAKG

Demidenko O, et al. "Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test." Aging (Albany NY). 2021; 13:24485-24499.

Azar Asadi Shahmirzadi, et al. “Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice.” doi:

Kjellman, Ulf W., et al. "Addition of α-ketoglutarate to blood cardioplegia improves cardioprotection." The Annals of Thoracic Surgery 63.6 (1997): 1625-1633

Kjellman, Ulf, et al. "α-ketoglutarate for myocardial protection in heart surgery." The Lancet 345.8949 (1995): 552-553

Jeppsson, Anders, et al. "Renal effects of α-ketoglutarate early after coronary operations." The Annals of Thoracic Surgery 65.3 (1998): 684-690.

Zimmermann, E., S. Wassmer, and V. Steudle. "Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism." Mineral and Electrolyte Metabolism22.1-3 (1996): 196-199.

Riedel, E., et al. "Calcium alpha-ketoglutarate administration to malnourished hemodialysis patients improves plasma arginine concentrations." Mineral and Electrolyte Metabolism22.1-3 (1996): 119-122.

Riedel, Eberhard, Michael Nündel, and Hannelore Hampl. "α-Ketoglutarate application in hemodialysis patients improves amino acid metabolism." Nephron 74.2 (1996): 261-265.

Birck, Rainer, et al. "Calcium ketoglutarate versus calcium acetate for treatment of hyperphosphataemia in patients on maintenance haemodialysis: a cross-over study." Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association-European Renal Association 14.6 (1999): 1475-1479.

Filip, et al. "Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: six-month study." International Journal for Vitamin and Nutrition Research 77.2 (2007): 89-97.

Wernerman, J., F. Hammarqvist, and E. Vinnars. "α-Ketoglutarate and postoperative muscle catabolism." The Lancet 335.8691 (1990): 701-703.

Wirén, Mikael, Johan Permert, and J. örgen Larsson. "α-ketoglutarate–supplemented enteral nutrition: effects on postoperative nitrogen balance and muscle catabolism." Nutrition 18.9 (2002): 725-728.

Mittal, Gaurav, et al. "Radiolabeling and dose fixation study of oral alpha-ketoglutarate as a cyanide antidote in healthy human volunteers." Clinical Toxicology 48.6 (2010): 509-515.

Bro, Susanne, et al. "Randomized crossover study comparing the phosphate-binding efficacy of calcium ketoglutarate versus calcium carbonate in patients on chronic hemodialysis." American Journal of Kidney Diseases 31.2 (1998): 257-262.

Blomqvist, Britt I., et al. "Glutamine and α-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement." Metabolism 44.9 (1995): 1215-1222.

Hammarqvist, F., J. Wernerman, and E. Vinnars. "Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery." Surgery 109.1 (1991): 28-36.

Click Here to Download Additional Peer Reviewed Studies

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. 

Based on human and mammalian studies.

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