10 min readA retrospective study of 42 healthy individuals using Rejuvant (Ca-AKG + gender-specific vitamin) over 7 months showed an average reduction of 8 years in biological age, measured by DNA methylation clocks. The benefit was robust across age and sex and especially pronounced in older participants. This is the first published human evidence showing such a marked age reversal using Rejuvant’s specific form of CaAKG.
This review explores AKG’s role in preventing muscle atrophy and enhancing regeneration. In preclinical and human studies, AKG improves satellite cell proliferation and muscle repair, reduces inflammation through macrophage polarization, and enhances endurance and recovery in active individuals. It also activates mTOR and boosts energy production under stress, highlighting its relevance for aging muscle, injury recovery, and performance support.
AKG directly scavenges reactive oxygen species (ROS) like hydrogen peroxide, converting them into harmless byproducts through oxidative decarboxylation. It also fuels ATP production via the TCA cycle and promotes synthesis of glutamine and glutamate, critical to redox balance. Studies show AKG reduces oxidative stress across organs including brain, liver, and gut—highlighting its therapeutic potential in aging and inflammation-related disorders.
In two large cohorts of middle-aged mice, dietary Ca-AKG extended lifespan (up to 20% in females) and compressed morbidity—delaying frailty more than it extended life. Mice showed lower inflammation, increased IL-10 production (a key anti-inflammatory cytokine), improved coat condition, and better gait. These findings support AKG’s role in modulating age-related inflammatory signaling (SASP) without eliminating senescent cells.
This review outlines how AKG regulates multiple hallmarks of aging: it modulates mTOR and ATP synthase, supports stem cell function, and modulates DNA/histone demethylation. In C. elegans, flies, and mice, AKG supplementation increases lifespan and healthspan. In humans, AKG levels decline ~10x from age 40 to 80, suggesting that supplementation could restore critical metabolic and epigenetic functions lost with age.
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