science supporting rejuvant

Rejuvant Outperforms All Other Supplements, Including Standard AKG and NAD+ in Landmark <em>Aging Cell</em> Study Preview

3 min read

Rejuvant Outperforms All Other Supplements, Including Standard AKG and NAD+ in Landmark Aging Cell Study

Ponce De Leon Health highlights a landmark independent peer-reviewed study in Aging Cell showing that among 84 supplements tested, only Rejuvant achieved statistical significance — associated with an average 1.8-year lower biological age residual. Standard CaAKG was 8× less effective; NMN/NR were 9× less effective. Both Dr. Brian Kennedy and Dr. Nir Barzilai commented on the findings.

highlighted studies

Aging journal

Rejuvant Reduces Biological Age by 8 Years in Humans

A retrospective study of 42 healthy individuals using Rejuvant (CaAKG + gender-specific vitamin) over 7 months showed an average reduction of 8 years in biological age, measured by DNA methylation clocks. The benefit was robust across age and sex and especially pronounced in older participants. This is the first published human evidence showing such a marked age reversal using Rejuvant’s specific form of CaAKG.

Nutrients

AKG Supports Muscle Health, Recovery, and Endurance

This review explores AKG’s role in preventing muscle atrophy and enhancing regeneration. In preclinical and human studies, AKG improves satellite cell proliferation and muscle repair, reduces inflammation through macrophage polarization, and enhances endurance and recovery in active individuals. It also activates mTOR and boosts energy production under stress, highlighting its relevance for aging muscle, injury recovery, and performance support.

BioMed Research International

The Antioxidative Function of AKG and Its Applications

AKG directly scavenges reactive oxygen species (ROS) like hydrogen peroxide, converting them into harmless byproducts through oxidative decarboxylation. It also fuels ATP production via the TCA cycle and promotes synthesis of glutamine and glutamate, critical to redox balance. Studies show AKG reduces oxidative stress across organs including brain, liver, and gut—highlighting its therapeutic potential in aging and inflammation-related disorders.

Cell Metabolism

AKG Extends Lifespan and Healthspan in Mice

In two large cohorts of middle-aged mice, dietary CaAKG extended lifespan (up to 20% in females) and compressed morbidity—delaying frailty more than it extended life. Mice showed lower inflammation, increased IL-10 production (a key anti-inflammatory cytokine), improved coat condition, and better gait. These findings support AKG’s role in modulating age-related inflammatory signaling (SASP) without eliminating senescent cells.